In addition to watching your caloric intake, another way to lose weight while taking antipsychotic medications is to exercise on a daily basis according to livestrongcom , “get moving. How to lose weight on antipsychotic medication. Jan 8, 2008 -- the diabetes drug metformin-- especially with a diet/exercise regimen -- largely reverses the weight-gain side effect of antipsychotic drugs antipsychotic medications-- especially.
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