How weight loss can help your knee osteoarthritis in one study, people who lost at least 10% of their weight had more relief in pain and inflammation than people who lost less than that. Losing weight help knee pain. The study of overweight and obese older adults with pain from knee oa found that greater weight loss resulted in better outcomes than losing a smaller amount of weight losing 10–20 percent of starting bodyweight improved pain, function, and quality of life better than losing just five percent of bodyweight reduce inflammation.
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